The Foundational Layer of Genomics
Minos is a decentralized genomic variant-calling network running on Bittensor Subnet 107. Miners compete to produce the most accurate variant calls from sequencing data. Validators score results against truth sets — accuracy is the only thing that matters.SN107 rewards miners based on the quality of their genomic variant calls.
How Minos Works
1
Receive Task
Validators send miners a genomic region and aligned sequencing reads (BAM) to analyze.
2
Call Variants
Miners run one of the four supported variant callers with their own tuned hyperparameters to produce variant calls (VCF) and share their hyperparameter config with validators for scoring.
3
Get Scored
Validators generate the VCF using the miner’s config and benchmark against a truth set using precision, recall, and F1-score.
Supported Variant Callers
Minos supports 4 industry-standard tools. Each guide covers the tool’s algorithm, pipeline, and every tunable hyperparameter.GATK HaplotypeCaller
The Broad Institute’s flagship caller. Performs local de novo assembly of haplotypes — Assembly-based approach for haplotype-aware calling.
Google DeepVariant
Deep learning variant caller. Converts pileups into CNN image classification — platform-aware models for WGS, WES, and PacBio.
FreeBayes
Bayesian haplotype-based caller with the most tunable priors — toggle HWE, allele balance, and contamination models independently.
BCFtools
The fastest caller. Classic pileup-based approach with a two-stage pipeline giving independent control over data prep and genotyping.
Quick Links
Architecture
How the subnet works end-to-end.
Quickstart
Get mining in under 10 minutes.
GitHub
Source code and issue tracker.