Subnet Overview
Minos (SN107) is a merit-based competition for genomic variant calling on the Bittensor network. The system has two roles:Miners
Share their hyperparameter configuration for running variant-calling tools (GATK, DeepVariant, FreeBayes, or BCFtools). Compete on call accuracy.
Validators
Distribute tasks, benchmark results against truth sets, and assign scores that determine ALPHA rewards.
The Scoring Loop
1
Task Distribution
A validator selects a genomic region with a known truth set. It sends the miner aligned reads (BAM) and a reference genome for that region.
2
Variant Calling
The miner runs their chosen variant caller with their tuned hyperparameters. The output they share with the validator is their hyperparameter config.
3
Benchmarking
The validator uses the miner’s config to generate a VCF, then compares it against the truth set using standard metrics:
- Precision — what fraction of called variants are real
- Recall — what fraction of real variants were found
- F1-score — harmonic mean of precision and recall
4
Reward
Miners are ranked by accuracy. Higher accuracy earns more ALPHA. The system is purely meritocratic — only call quality matters.
Why Hyperparameters Matter
Every variant caller has dozens of tunable parameters that control sensitivity, specificity, and how the algorithm processes data. The default settings are general-purpose — they are not optimized for any specific benchmark. Miners who understand and tune these parameters gain a competitive edge:
The Miner Guides document every parameter for each supported tool.