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The Foundational Layer of Genomics

Minos is a decentralized genomic variant-calling network running on Bittensor Subnet 107. Miners compete to produce the most accurate variant calls from sequencing data. Validators score results against truth sets — accuracy is the only thing that matters.
SN107 rewards miners based on the quality of their genomic variant calls.

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How Minos Works

1

Receive Task

Validators send miners a genomic region and aligned sequencing reads (BAM) to analyze.
2

Call Variants

Miners run one of the four supported variant callers with their own tuned hyperparameters to produce variant calls (VCF) and share their hyperparameter config with validators for scoring.
3

Get Scored

Validators generate the VCF using the miner’s config and benchmark against a truth set using precision, recall, and F1-score.

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Supported Variant Callers

Minos supports 4 industry-standard tools. Each guide covers the tool’s algorithm, pipeline, and every tunable hyperparameter.

GATK HaplotypeCaller

The Broad Institute’s flagship caller. Performs local de novo assembly of haplotypes — Assembly-based approach for haplotype-aware calling.

Google DeepVariant

Deep learning variant caller. Converts pileups into CNN image classification — platform-aware models for WGS, WES, and PacBio.

FreeBayes

Bayesian haplotype-based caller with the most tunable priors — toggle HWE, allele balance, and contamination models independently.

BCFtools

The fastest caller. Classic pileup-based approach with a two-stage pipeline giving independent control over data prep and genotyping.

Architecture

How the subnet works end-to-end.

Quickstart

Get mining in under 10 minutes.

GitHub

Source code and issue tracker.